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Vita D3 40000 IU Capsule 5pcs
Cholecalciferol [Vitamin D3] 40000IU is used for the treatment of Osteoporosis, Hypoparathyroidism, Rickets, Osteomalacia, Vitamin D Deficiency, Pseudohypoparathyroidism, Familial hypophosphatemia
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✅ Description:
Vitamin D3 Deficiency: Occurs in individuals with limited sunlight exposure or insufficient dietary intake. Essential for calcium and phosphate absorption, healthy bones, and teeth. Prevents rickets, osteomalacia, osteoporosis, and pre-eclampsia during pregnancy. Crucial for infant growth and immune function.
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✔️ Pharmacology
- Active Form: Calcitriol binds to Vitamin D receptors (VDRs) distributed in body tissues.
- Half-life: Approximately 50 days (fat-soluble).
- Absorption & Metabolism:
- Absorbed in the small intestine.
- Transported to the liver and metabolized to 25-hydroxy Vitamin D3 (Calcidiol).
- Further hydroxylation in the kidney to 1,25-dihydroxy Vitamin D3 (Calcitriol), which increases calcium absorption.
- Stored in fat and muscle tissues.
- Eliminated via feces and urine.
✔️ Side Effects
- Rarely includes anorexia, lassitude, nausea, vomiting, diarrhea, constipation, weight loss, polyuria, sweating, headache, thirst, vertigo, and raised calcium and phosphate levels in plasma and urine.
✔️ Capsules:
- Adults:
- Treatment: 40,000 IU once weekly for 7 weeks. Maintenance: 1,400-2,000 IU/day.
- Prevention: 20,000 IU every 4 weeks. Higher doses may be required.
- Osteoporosis addition: 20,000 IU once a month.
- Children (12-18 years):
- Treatment: 20,000 IU every 2 weeks for 6 weeks.
- Prevention: 20,000 IU every 6 weeks.
- Deficient Patients:
- 0-1 year: 2,000 IU/day (+50,000 IU/week for 6 weeks).
- 1-18 years: 2,000 IU/day for 6 weeks.
✔️ Overdose Effects
- Can lead to hypervitaminosis D.
✔️ Use in Special Populations
- Safety and efficacy in children under 12 years not established.
✔️ Interactions
- Drugs that cause Vitamin D3 deficiencies by interfering with its absorption/metabolism include Magnesium-containing antacids, Digoxin, Thiazide diuretics, Cholestyramine, Cholistipol, Phenytoin, Phenobarbital, Orlistat, Mineral Oil, and Corticosteroids (e.g., Prednisolone).
✔️ Contraindications
- Hypercalcemia or known hypersensitivity to Vitamin D3 or its excipients.
- Evidence of Vitamin D3 toxicity.
✔️ Pregnancy & Lactation
- Safe use up to 4,000 IU during pregnancy. Daily intake recommendation: 400 IU. Higher doses may be required for deficient women.
- Excreted in breast milk; no overdose observed in infants from nursing mothers. Consider additional Vitamin D3 for breast-fed children.
✔️ Precautions & Warnings
- Monitor plasma calcium in high doses, renal impairment, and during pregnancy/lactation.
- Consult a healthcare practitioner for patients on Digoxin, Thiazide diuretics, or with liver/kidney disease, hyperthyroidism, lymphoma, tuberculosis, or granulomatous disease.
✔️ Storage Conditions
Store below 30ºC, protected from light and moisture. Keep out of reach of children.
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